ABSTRACT
The clinical application of triptolide (TPL) in tumor therapy has been greatly limited by its toxicity and inefficient delivery. Herein, a localized and sustained-release thermo-sensitive hydrogel was developed for the intra-tumor administration of TPL. Based on the amphiphilic structure of poly (
ABSTRACT
The suitable experimental animal model is important in research of pathogenesis and therapeutic strategies of diabetic foot ulcer, and the murine model is the most commonly used one at present. It can be divided into two types: the animal model simulating pathological conditions and the model simulating clinical symptoms. This article reviews the current research progress on the mechanisms of diabetic ulcer pathogenesis, and relevant treatment strategies, including the inhibition of matrix metalloproteinases (MMPs) expression, promotion of angiogenesis and anti-inflammatory therapy.
Subject(s)
Animals , Humans , Mice , Anti-Inflammatory Agents , Therapeutic Uses , Diabetic Foot , Genetics , Therapeutics , Disease Models, Animal , Matrix Metalloproteinase Inhibitors , Therapeutic Uses , Matrix Metalloproteinases , Genetics , Metabolism , Neovascularization, Physiologic , PhysiologyABSTRACT
Diabetes,so-called“emaciation-thirst disease”in traditional Chinese medicine(TCM),is a prevalent chronic dis?ease with complicated etiology,incurable and multiple complications,as well as extremely high morbidity and mortality. TCM pays at?tention to tackling the problem in the treatment of emaciation-thirst disease,and many prescriptions are single animal medicine or con?tain animal-original drug;animal-original drugs possess stasis and other unique characteristics and therapeutic effects. Based on the current anti-diabetic drugs,the review gives an in-depth summary and analysis on the single animal-original drugs derived from the complexes of TCM in the treatment of diabetes according to their mechanism of action,with the aim to provide reference for developing new animal-original drugs to treat diabetes.